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Diagnostic

National Health Laboratory Service

CONTACTS
Consultant-in-charge Routine C17 lab Dr Jessica Opie Tel: 404-3082 Fax: 404-4105 
Consultant-in-charge Red Cross Hospital lab Dr Lee Ann Phillips Tel: 658-5228 Fax: 658-5206
Lab Manager NHLS Path labs Dr Lucille Human Tel: 404-4186 Fax: 404-5281
Lab Manager (C17) Haematology Mrs Delmaine Rousseau Tel: 404-4136 Fax: 404-4105
Lab Manager (RXH) Haematology Zulfa Abrahams Tel: 658-5142 Fax: 658-5206
Consultant Haematology Dr Emil Beltchev Tel: 404-3081 Fax: 404-4105
Consultant Haematology Dr Mona Lisa Ntobongwana Tel: 404-4244  
Consultant Haematology Dr Nomusa Mashigo    
Medical Scientist Molecular Biology lab C21 Dr Karen Shires Tel: 406-6673  


LABS:

  • Routine diagnostic laboratory (C17 - Groote Schuur Hospital)
     
  • Molecular Laboratory (C21 - Groote Schuur Hospital)
     
  • Routine diagnostic laboratory (Red Cross Children's Hospital)

Routine diagnostic laboratory (C17 - GSH): 

The C17/GSH Haematology Laboratory offers a combined Routine and Emergency (24 hours a day STAT) diagnostic service to Groote Schuur Hospital, as well as to some peripheral hospitals such as Mowbray Maternity, Victoria Hospital and False Bay Hospitals. This includes testing of full blood counts and differentials as well routine coagulation testing. 
The Antenatal Laboratory also tests haemoglobins and antibody testing for numerous of the MOU's in the Cape Peninsula as well as the Western Cape. As part of the ARV treatment program, CD4 flow cytometry also forms part of the routine testing.
Many of the specialised tests that we offer are not performed in regional laboratories, so samples are received from both Western Cape and Eastern Cape Hospitals and Clinics plus a number of private facilities for:

  • Bone marrow biopsies for the diagnosis and management of numerous haematological malignancies as well as RVD patients to investigate for disseminated TB or other infiltrations
     
  • Flow cytometry which is used to classify leukemias and lymphomas as part of either the diagnostic workup or management of the patient during treatment
     
  • Testing of patients with Haemophilia
     
  • Testing of patients for haemoglobinopathies
     
  • Molecular testing by PCR is offered for a number of haematological diseases including Chronic Myeloid Leukaemia (BCR-ABL), other myeloproliferative Disorders (JAK2) and Acute Promyelocytic Leukaemia (PML-RARA). Further tests are regularly becoming available.

C17 lab group

Routine diagnostic molecular & cytogenics laboratory (C21 - GSH):

Cytogenetics and FISH

Molecular testing by PCR is offered for a number of haematological diseases including Chronic Myeloid Leukaemia (BCR-ABL), other myeloproliferative Disorders (JAK2) and Acute Promyelocytic Leukaemia (PML-RARA). Further tests are regularly becoming available.

Molecular tests currently on offer:

JAK2V617F Chronic Myeloproliferative Disorder (Ph negative) confirmatory test
BCR/ABL p190 and p210 qualitative assay Diagnostic Chronic Myeloid Leukemia (CML) assay
BCR/ABL p210 quantitative assay Monitoring of CML patients
ABL kinase mutation detection assay Assessment of treatment resistance mutations in CML patients
PML/Raralpha detection assay Diagnosis and monitoring disease in Acute Promyelocytic leukemia (APL) patients
FLT3 ITD detection assay Prognostic assay for Acute Myeloid Leukemia patients with normal cytogenetics
Factor V leiden/Prothrombin/MTHFR point mutation assay Inherited Thrombosis risk factors

FISH image t(15;17)

(Red Cross Children's Hospital)

Haematology Routine Diagnostic Laboratory :

Red Cross Children's Hospital UCT/NHLS Division of Haematology provides a 24 hour paediatric routine and specialized academic haematology service to the Red Cross and Mowbray Maternity Hospitals in Cape Town. It is particularly geared for processing small sample volumes. The unit specialises in the diagnosis and management of a wide range of haematological disorders in children. The laboratory provides a full diagnostic service for leukaemia, including bone marrow biopsies, cytochemistry, immunophenotyping and cytogenetic and molecular analysis.  A full spectrum of haemolytic and coagulation assays are performed for both congenital and acquired disorders. Furthermore, the laboratory receives many referred samples both from other NHLS centres and from private practice pathologists.  The laboratory provides a comprehensive diagnostic and consultation service to clinicians regarding paediatric diseases.
 

Contact us at:

Institute of Child Health Building:  Ground Floor
Red Cross Children's Hospital
Rondebosch
Cape Town
South Africa
7700

Tel:   021 658 5203/4/5
Fax:  021 658 5206

Clinical Trials: 

The Haematology Laboratory, is part of the co-operative that offers a Clinical Trials service both to the Pharmaceutical companies and to Clinicians performing academic studies. 
For further information, please contact:
Chemical Pathology Clinical Trials Manager, Dr Heleen Vreede